药物设计与发现

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药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)

11C-labeling, 126–127 126 127

18F-labeling, 127–128 127 128

metabolism, 128–129 128 129

physical principle, 121–122 121 122

radionuclides selection

advantages, 124 124

11C and 18F, 125 125

antagonists, 207–208 207 208

binding vs. functional assays, 206–207 206 207

constitutively active receptors and inverse

agonism, 209 209

negative allosteric modulators, 208, 210–211 208 210 211

partial and full agonists, 206–207 206 207

positive allosteric modulators, 210 210

recombinant vs. insitu assays, 204, 206 204 206

structure and function

Cys-loop receptor family, 199–200 199 200

GPCRs, 196–199 196 199

ionotropic glutamate receptor family, 201–202 201 202

nuclear receptors, 203–204 203 204

purinergic P2X receptor family, 202–203 202 203

tyrosine kinase receptors, 202–205 202 205

synaptic processes and mechanisms, 195–196 195 196

Re-entry arrhythmia, 220 220

Rifamycin B, 112 112

RNAi, see RNA interference

RNA interference (RNAi), 96–98 96 98

RNAP, see RNA polymerase

RNA polymerase (RNAP), 418–419 418 419

bacterial, 418 418

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