药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
bioassay-guided fractionation, 107 107
fractionated screening samples, 110–111 111
natural structure-activity relationship, 107 107
target-based screening, 108–109 109
semisynthesis, 111–112 112
NCL, see Native chemical ligation 0
Negative allosteric modulators (NAMs), 208,210–211, 282 282
Neurotransmitter transporters 0
biogenic amine transporters, 241 241
amphetamine, 241, 243–244 244
antidepressants, 241, 244–245 245
benztropine, 241, 243 243
glycine and GABA transporters, 245–246 246
phenoxymethyl penicillin (penicillin V), 408 408
6-aminopenicillanic acid, 408 408
Peptide and protein drug design 0
design process, 138–139 139
historical perspective, 137–138 138
Peptide and protein engineering 0