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药物设计与发现 1119条(本栏目收费,不能显示细节,电话13136136841)
transporter ligands, 312–316
312 316
amino acid sequence, 193–194
193 194
G protein-coupled receptors, 194
194
ligand-gated ion channels, 194
194
Unncompetitive inhibitors, 176
176
van der Waals energy interactions, 26
26
“Venus flytrap” mechanism, 54–55
54 55
Voltage-gated ion channels; see also Ion channels
auxiliary subunits, 227
227
CaV1 family (L-type currents), 225–227
225 227
CaV2 family (N-, P/Q-, and R-type current), 223,225, 227
223 225 227
CaV3 family (T-type currents), 225, 227
225 227
physiological roles, 220, 223–224
220 223 224
structure and molecular biology, 222–224
222 224
glibenclamide, 220–221
220 221
Kir3 channels, 219–220
219 220
pancreatic β-cells and insulin secretion, 220
220
re-entry arrhythmia, 220–221
220 221
TRP cation channels, 222
222