药物设计与发现 1119条(本栏目收费,不能显示细节,电话15274084725)
transporter ligands, 312–316 316
amino acid sequence, 193–194 194
G protein-coupled receptors, 194 194
ligand-gated ion channels, 194 194
Unncompetitive inhibitors, 176 176
van der Waals energy interactions, 26 26
“Venus flytrap” mechanism, 54–55 55
Voltage-gated ion channels; see also Ion channels 0
auxiliary subunits, 227 227
CaV1 family (L-type currents), 225–227 227
CaV2 family (N-, P/Q-, and R-type current), 223,225, 227 227
CaV3 family (T-type currents), 225, 227 227
physiological roles, 220, 223–224 224
structure and molecular biology, 222–224 224
glibenclamide, 220–221 221
Kir3 channels, 219–220 220
pancreatic β-cells and insulin secretion, 220 220
re-entry arrhythmia, 220–221 221
TRP cation channels, 222 222