药物和生物制品的冷冻干燥冻干

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药物和生物制品的冷冻干燥冻干 1367条(本栏目收费,不能显示细节,电话13136136841)

effects on solute,58 58

of glycine,148 148

of sodium chloride,113 113

solvents and,261,269 261 269

velocity of solution vs. degree of supercooling,7 7

of water,37 37

weight fraction of,148 148

Crystallization temperature (Tcr),136 136

Cyclic olefin copolymers (COC),399 399

Cyclic olefin polymers (COP),399 399

Cyclodextrin cosolvents negative impact on,268 268

residual tert-butanol and,271 271

tert-butanol and,262,265,269 262 265 269

Deamidation,292 292

Degradation during freezing,207 207

rate freeze concentration on,201,202 201 202

rate relative permitivity and,260 260

solvents to minimize,259 259

at storage temperature,346,349 346 349

unfolding and minimizing,168 168

Dehydration amorphous components and,169,170 169 170

protein protection,169 169

protein stabilization by sugars,169,172 169 172

diluent-containing chamber,500,501 500 501

freeze-dry cycle development in,507,514 507 514

freezing,508,509 508 509

Carbon dioxide (CO2) in freeze-drying,277 277

Carbonmonoxymyoglobin (MbCO) system glass transition and,211 211

Case studies on freeze-dryer capability assessments,435,438 435 438

on freeze-drying time,434 434

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