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 药物和生物制品的冷冻干燥冻干 1367条(本栏目收费,不能显示细节,电话13136136841)
effects on solute,58 58
of glycine,148 148
of sodium chloride,113 113
solvents and,261,269 269
velocity of solution vs. degree of supercooling,7 7
of water,37 37
weight fraction of,148 148
Crystallization temperature (Tcr),136 136
Cyclic olefin copolymers (COC),399 399
Cyclic olefin polymers (COP),399 399
Cyclodextrin cosolvents negative impact on,268 268
residual tert-butanol and,271 271
tert-butanol and,262,265,269 269
Deamidation,292 292
Degradation during freezing,207 207
rate freeze concentration on,201,202 202
rate relative permitivity and,260 260
solvents to minimize,259 259
at storage temperature,346,349 349
unfolding and minimizing,168 168
Dehydration amorphous components and,169,170 170
protein protection,169 169
protein stabilization by sugars,169,172 172
diluent-containing chamber,500,501 501
freeze-dry cycle development in,507,514 514
freezing,508,509 509
Carbon dioxide (CO2) in freeze-drying,277 277
Carbonmonoxymyoglobin (MbCO) system glass transition and,211 211
Case studies on freeze-dryer capability assessments,435,438 438
on freeze-drying time,434 434
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