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 临床试验研究设计终点和生物标志物药物安全性 890条(本栏目收费,不能显示细节,电话13136136841)
Bonomi study,396 396 
BRCA1,332 332 
Breast cancer biomarkers,332–337 332 337 
gene array as prognostic factor,267–268 267 268 
health-related quality of life,397–398 397 398 
Ring study,258–259 258 259 
Contract research organization (CRO),445,447 445 447 
Council of International Organizations of Medical Sciences (CIOMS)adverse event classification,426 426 
CIOMS I form,450–451 450 451 
Coyne study,549–552 549 552 
C-reactive protein (CRP)biology,345–346 345 346 
biomarker applications atherosclerosis,349–351 349 351 
cancer,347–349 347 349 
overview,345,352–353 345 352 353 
inflammatory bowel disease levels,341 341 
Crohn’s disease C-reactive protein levels,341 341 
health-related quality of life,404–405 404 405 
CTCAE dictionary adverse event severity grading,442–443 442 443 
CTD see Common Technical Document Cumulative toxicity basis of exclusion,74–76 74 76 
Cytokines see also specific cytokines classification,476–477 476 477 
mechanism of action considerations in diseases with immune component,476–478 476 478 
modulation of immune system,483–484 483 484 
Czito schema,30 30 
types,387–388 387 388 
timing of questionnaires,386–387 386 387 
Hematological cancers see also specific cancers acute lymphocytic leukemia,284–287 284 287 
acute myeloid leukemia,289–291 289 291 
acute promyelocytic leukemia,291–292 291 292 
chronic lymphocytic leukemia,287–288 287 288 
chronic myeloid leukemia,293–294 293 294 
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