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 临床试验研究设计终点和生物标志物药物安全性 890条(本栏目收费,不能显示细节,电话13136136841)
warfarin,2–3 3
Drug resistance ABC transporters,76–77 77
cross-resistance,77–78 78
doxorubicin,78 78
exclusion criteria,76 76
imatinib,79–80 80
paclitaxel,78–79 79
tamoxifen,79 79
Dupont study,158 158
Dy schema,36–37 37
ECOG performance status,73–74 74
EDSS see Expanded Disability Status Scale Elixir Sulfanilamide,578–579 579
Endpoints clinical endpoint,191 191
hematological cancers event-free survival,311–313 313
relapse-free interval,313 313
mechanism of action and surrogate endpoints,473 473
multiple endpoints,194–195 195
Phase I trial,191 191
relatively objective endpoints versus relatively subjective endpoints,193–194 194
selection,194–195 195
start date,162–163 163
supportive care and health-related quality of life endpoint conflict,136 136
surrogate endpoint,191–192 192
Erlotinib,54 54
Blinding allocation concealment versus blinding,112–113 113
bias sources,124 124
overview,123–125 125
Reck schema,38–40 40
Blood cancers see Hematological cancers Blumenschein schema,28–30 30
Boceprevir,519 519
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