当前位置：药药网 / 医药文献 /临床前药物开发(本栏目收费,不能显示细节,电话13136136841)
关键字：
类型：
下载页码(大于等于0,小于558)：
临床前药物开发 107条(本栏目收费,不能显示细节,电话13136136841)
5.Pharmacokinetics/ADME of Large Molecules .........159
159
Rene Braeckman 1.Introduction ....159
159
2.Clearance Mechanisms of Protein Therapeutics ....160
160
3.Distribution of Protein Therapeutics ....171
171
4.Plasma Pharmacokinetics ....176
176
5.Protein Binding of Protein Therapeutics ....180
180
6.Interspecies Scaling ....182
182
7.Heterogeneity of Protein Therapeutics ....185
185
8.Chemical Modifications of Protein Therapeutics ....186
186
9.Immunogenicity ....188
188
10.Conclusions and Implications for Preclinical Drug Development ....191
191
6.Preclinical Pharmacokinetic–Pharmacodynamic Modeling and Simulation in Drug Development ...............199
199
Paolo Vicini and Peter L.Bonate 1.Introduction ....199
199
2.What Is a Model and Why Do We Make Them? ....200
200
3.What Conditions Are Necessary for the Preclinical Model to be Valid in Humans? ....200
200