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临床前药物开发 107条(本栏目收费,不能显示细节,电话13136136841)
5.Pharmacokinetics/ADME of Large Molecules .........159 159
Rene Braeckman 1.Introduction ....159 159
2.Clearance Mechanisms of Protein Therapeutics ....160 160
3.Distribution of Protein Therapeutics ....171 171
4.Plasma Pharmacokinetics ....176 176
5.Protein Binding of Protein Therapeutics ....180 180
6.Interspecies Scaling ....182 182
7.Heterogeneity of Protein Therapeutics ....185 185
8.Chemical Modifications of Protein Therapeutics ....186 186
9.Immunogenicity ....188 188
10.Conclusions and Implications for Preclinical Drug Development ....191 191
6.Preclinical Pharmacokinetic–Pharmacodynamic Modeling and Simulation in Drug Development ...............199 199
Paolo Vicini and Peter L.Bonate 1.Introduction ....199 199
2.What Is a Model and Why Do We Make Them? ....200 200
3.What Conditions Are Necessary for the Preclinical Model to be Valid in Humans? ....200 200