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临床前药物开发 107条(本栏目收费,不能显示细节,电话13136136841)
5.Limitations and Predictive Value of the Preclinical Database ....562
562
6.Conclusions ....563
563
4.Case Studies ....202
202
5.Conclusions ....217
217
7.Formulation and Route of Administration—Influencing Drug Permeability and Absorption .....................221
221
Mansoor A.Khan and Fakhrul Ahsan 1.Oral Drug Delivery ....222
222
2.Transdermal Drug Delivery ....229
229
3.Nasal Drug Delivery ....233
233
4.Pulmonary Drug Delivery ....241
241
5.Conclusions and Implications for Preclinical Drug Development ....244
244
8.Assessment of Pharmacokinetics and Drug Activity: Isolated Organ Systems and the Membrane Transporter Family .........251
251
Kevin R.Sweeney and David R.Taft 1.Introduction ....251
251
2.Overview of Membrane Transporters ....252
252
3.Experimental Methods Used to Study Membrane Drug Transport ....259
259
4.Hepatobiliary Transport ....263
263
5.Gastrointestinal Transport ....271
271
6.Renal Transport ....276
276
7.Central Nervous System Transport ....281
281
8.Impact of Membrane Transporters on Other Organs and Tissues ....287
287
9.Implications for Preclinical Drug Development ....287
287
9.Alternate Methods for Assessing Absorption, Metabolism,and Routes of Elimination .......303
303
Peter Bullock 1.Introduction ....303
303
2.The Evolution of Drug Discovery and Its Effect on Preclinical Development ....305
305
3.Lead Selection and Optimization via Pharmaceutical Profiling ....307
307