临床前药物开发 107条(本栏目收费,不能显示细节,电话13136136841)
5.Limitations and Predictive Value of the Preclinical Database ....562 562
6.Conclusions ....563 563
4.Case Studies ....202 202
5.Conclusions ....217 217
7.Formulation and Route of Administration—Influencing Drug Permeability and Absorption .....................221 221
Mansoor A.Khan and Fakhrul Ahsan 1.Oral Drug Delivery ....222 222
2.Transdermal Drug Delivery ....229 229
3.Nasal Drug Delivery ....233 233
4.Pulmonary Drug Delivery ....241 241
5.Conclusions and Implications for Preclinical Drug Development ....244 244
8.Assessment of Pharmacokinetics and Drug Activity: Isolated Organ Systems and the Membrane Transporter Family .........251 251
Kevin R.Sweeney and David R.Taft 1.Introduction ....251 251
2.Overview of Membrane Transporters ....252 252
3.Experimental Methods Used to Study Membrane Drug Transport ....259 259
4.Hepatobiliary Transport ....263 263
5.Gastrointestinal Transport ....271 271
6.Renal Transport ....276 276
7.Central Nervous System Transport ....281 281
8.Impact of Membrane Transporters on Other Organs and Tissues ....287 287
9.Implications for Preclinical Drug Development ....287 287
9.Alternate Methods for Assessing Absorption, Metabolism,and Routes of Elimination .......303 303
Peter Bullock 1.Introduction ....303 303
2.The Evolution of Drug Discovery and Its Effect on Preclinical Development ....305 305
3.Lead Selection and Optimization via Pharmaceutical Profiling ....307 307