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 药物开发过程:提高效率和成本效益 328条(本栏目收费,不能显示细节,电话13136136841)
laboratory at Zeneca, 388-394, 401-404, 408-411, 415 388 394  401 404  408 411  415 
and preclinical studies, 379-380 379 380 
role in drug development process, 379-384 379 384 
support of Phase I trials, 394-395 394 395 
11. Clinical Pharmacology in Drug Development: A View to Future Effectiveness J. Robert Powell, Alan Bye, and Paul D. Rubin 295 
12. Contracting CROs into Your Organization: New Strategies for New Challenges Gary D. Lightfoot and John R. Vogel 317 
13. The Role of Clinical Research Organizations in Drug Development Albert J. Siemens and James E. Higgins 377 
Part VII: European and Japanese Approaches 
14. Understanding Drug Development and Registration in Japan W. J. C. Currie 353 
Page xv 
15. Increasing the Effectiveness of Clinical Pathology Testing and Its Value to Drug Development in Europe Dai Davies and Karolyn Jackson 377 
16. New Marketing Authorization Procedures in the European Union and the Impact on Regulatory Strategy Vaila M. Marshall 421 
Index 443 
A-II antagonists, 20 20 
Absorption enhancer, 9 9 
Academicians, 12 12 
ACE inhibitors, 20, 24, 26, 28 20  24  26  28 
Action Potential Duration (APD), 23 23 
Amiodarone, 7 7 
Anticancer drugs, 282-293 282 293 
animal toxicology of, 284-285 284 285 
dose escalation schemes, 287-289 287 289 
phase I trials, 285-290 285 290 
phase II trials, 290-291 290 291 
phase III trials, 291-292 291 292 
Bayh-Dole Act, 61 61 
Biodiversity, 5 5 
Bioinformatics, 209 209 
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