新型冠状病毒2019硅疫苗设计与药物发现 67条(本栏目收费,不能显示细节,电话13136136841)
9.3 Antigenic Site Prediction by EMBOSS ANTIGENIC........ 70 70
9.4 Identification of Peptide with Highest Antigenic Propensity Using EMBOSS Antigenic Tool............ 70 70
9.5 Construction of Peptide 3D Structure in Argus Lab......... 72 72
9.6 Conclusion.......... 73 73
10 COVID19 Rapid Diagnostic Kits................ 75 75
10.1 Principle and Working of LabCorp COVID19 RT-PCR Test Kit............ 75 75
10.2 RAPID Test Kit for COVID Detection Based on Antibodies Identification........ 77 77
1.3 SARS Corona Virus 2......... 5 5
1.4 World Health Organization Response towards COVID19..... 6 6
2 Genomics and Evolution of Novel Corona Virus 2019.......... 9 9
2.1 Important Regions Within the Novel Corona Virus Genome [2]......... 9 9
2.2 Linking NCoV with SARS and determining its genomic conservation......... 10 10
3 Comparing Proteomics of NCoV 19 and MERS Corona Virus.... 13 13
3.1 ORF1ab Protein Sequence comparison of NCoV and MERS CoV...... 14 14
3.2 Comparison of Spike (S) Proteins of NCoV and MERS CoV...... 18 18
3.3 Comparison of Membrane (M) Proteins of NCoV and MERS CoV...... 19 19
3.4 Comparison of Envelope (E) Proteins of NCoV and MERS CoV...... 20 20
3.5 Comparison of Nucleocapsid (N) Proteins of NCoV and MERS CoV...... 21 21
3.6 Conclusion.......... 22 22
4 Physiochemical Characterization and Domain Annotation of ORF1ab Polyprotein of Novel Corona Virus 19............. 23 23
4.1 Physiochemical Characterization of ORF1ab Polyprotein Using Protparam...... 23 23
4.2 Identification of Domains within the ORF1ab Polyprotein using SMART....... 24 24
4.3 The region 4406–5900 of ORF1ab polyprotein of NCoV..... 30 30
4.4 The Secondary Structural Conformations of the Region 4406–5900.......... 31 31
4.5 3D Structure prediction using Phyre.......... 31 31