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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)
“3 + 3” study, 397–398
397 398
chronic disease/conditions, 399
399
positive signal identification, 399–400
399 400
randomized phase II trial, 401, 401f
401 401
single arm phase II study, 400–401,400f
400 401 400
staged trial design, 401, 401f
401 401
trial design and outcome measure, 400
400
crossover trial design, 405–406, 405f
405 406 405
financial risk, 402–403
402 403
non-life-threatening conditions, 407
407
objective endpoints, 405
405
patient management vs. candidate
placebo control group, 404
404
subjective endpoints, 405
405
pharmacoeconomic studies, 408
408
safety and efficacy, 407–408
407 408
Comet assay, 359, 359f
359 359
Competitive inhibitors, 101–103, 103f
101 103 103
Computational chemistry, 50–53, 51f–52f
50 53 51 52
Congestive heart failure (CHF), 329–332, 330f
329 332 330