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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)
Enzymatic metabolism, 277–278
277 278
Enzyme-linked immunosorbent assay
activation energy, 97–99, 98f
97 99 98
allosteric inhibitors, 103f, 104
103 104
classes of, 95–96, 96f
95 96 96
cofactors/coenzymes, 99, 101f
99 101
competitive inhibitors, 101–103, 103f
101 103 103
induced fit, 97, 98f
97 98
irreversible inhibitors, 103f, 104–105
103 104 105
redox active compounds, 99–101, 102f
99 101 102
European Medicines Agency (EMA), 73–74
73 74
Fatty acid synthase, 96
96
Flavin monooxygenase (FMO) family,273–274
273 274
Fluorescence-based assay systems,164–165, 164f
164 165 164
Fluorescence polarization (FP)
antibody technology, 167, 167f
167 167
DNA/protein interactions, 168, 168f
168 168
polarized irradiation, 166–167, 167f
166 167 167
polarized vs. depolarized emission,165–166, 166f
165 166 166
protein/protein interactions, 168, 168f
168 168
Fluorescence resonance energy transfer (FRET) biochemical process, 171–172
171 172
cell surface protein, 169–170, 170f
169 170 170
cyan fluorescent protein (CFP),170–171
170 171
donor/acceptor pair, 168
168
GPCR activity, 170–171
170 171