药物发现和开发的基本原则

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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)

BCS. See Biopharmaceutics Classification

System (BCS)

Benzylpenicillin, 104–105, 105f 104 105 105

Biginelli reaction, 54, 55f 54 55

Bioisosterism

bioisosteric replacement, 235–236 235 236

carbenicillin, 234–235, 235f 234 235 235

classic, 232–233, 232t, 233f 232 233 232 233

non-classic, 234–235, 234f 234 235 234

Biologics Price Competition and

Innovation Act, 77–78 77 78

pharmacokinetic properties, 25 25

safety and side-effect profiles, 26 26

screening tree, 21–22, 22f 21 22 22

Clinical trials

adaptive clinical trial design, 409 409

definition, 386 386

delivery methods, 389–391 389 391

dosing regimen schedule, 389, 389f 389 389

IV-delivery, 390–391 390 391

oral delivery, 389–390 389 390

Dipeptidyl peptidase IV (DPP-IV)

Abbreviated New Drug Application (ANDA), 75–76, 471–472 75 76 471 472

Absorption, distribution, metabolism, and excretion (ADME) absorption, 249 249

distribution, 262–264, 263f–264f 262 264 263 264

elimination pathways, 270–271 270 271

excretion, 283–287, 284f–286f 283 287 284 286

metabolism. See Metabolism, in vivo

ADME properties

microsomal stability. See Liver

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