药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)
BCS. See Biopharmaceutics Classification 0
Benzylpenicillin, 104–105, 105f 105
Biginelli reaction, 54, 55f 55
bioisosteric replacement, 235–236 236
carbenicillin, 234–235, 235f 235
classic, 232–233, 232t, 233f 233
non-classic, 234–235, 234f 234
Biologics Price Competition and 0
pharmacokinetic properties, 25 25
safety and side-effect profiles, 26 26
screening tree, 21–22, 22f 22
adaptive clinical trial design, 409 409
delivery methods, 389–391 391
dosing regimen schedule, 389, 389f 389
oral delivery, 389–390 390
Dipeptidyl peptidase IV (DPP-IV) 0
Abbreviated New Drug Application (ANDA), 75–76, 471–472 472
Absorption, distribution, metabolism, and excretion (ADME) absorption, 249 249
distribution, 262–264, 263f–264f 264
elimination pathways, 270–271 271
excretion, 283–287, 284f–286f 286
metabolism. See Metabolism, in vivo 0
microsomal stability. See Liver 0