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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)
Animal models, disease states (Continued )
isomorphic animal models, 312
312
knockout animal models, 45–47, 47f
45 47 47
neuroscience animal model
contextual fear conditioning model,317–318, 318f
317 318 318
elevated plus maze, 315–316, 316f
315 316 316
forced swimming test, 315, 315f
315 315
amyotrophic lateral sclerosis, SOD1-G93A mouse, 320–321, 321f
320 321 321
Parkinson’s disease, MPTP Model,321–323, 322f
321 323 322
novel object recognition test, 316–317,317f
316 317 317
number of animals, 314
314
oncology animal model, 335–336
335 336
genetically engineered mouse (GEM)
mouse allograft tumor model, 337–338
337 338
calcium-sensing receptor, 280–281
280 281
GPCR’s natural ligand block, 177–178
177 178
postsynaptic nAChR, 121–122
121 122
YFP fluorescence, 170–171
170 171
Antihypertensive agents, 323, 325
323 325
Automated uHTS system, 55–56, 56f
55 56 56
BACE inhibitors. See β-Secretase (BACE)