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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)
anti-target activity, 364–365
364 365
cardiac action potential, 362–363, 363f
362 363 363
cardiovascular targets, 367, 367t
367 367
electrophysiological patch clamp studies,366
366
[3H]-dofetilide displacement, 364–365,364f
364 365 364
in vitro screening systems, 366–367
366 367
Langendorff preparation, 367–368, 368f
367 368 368
myocyte action potential, 363–364, 363f
363 364 363
neurohormonal modulation, 367–368
367 368
ischemic heart disease, 329–330
329 330
myocardial infarction, 330–331
330 331
non-surgical rodent models, 332
332
tachycardia-induced AF model., 331
331
tachycardia-induced HF model, 331
331
hypertension. See also Hypertension
deoxycorticosterone acetate (DOCA), 323–324, 324f2K1C model, 323, 324f
323 324 324 323 324
spontaneously hypertensive rat (SHR), 324
324
telemetry-driven animal system, 325
325
homologous animal models, 312
312
infectious disease animal model, 332
332
influenza virus infection, 334
334
murine thigh infection model,332–333, 333f
332 333 333
systemic infection, murine model,333–334, 334f
333 334 334
transgenic animal models, 44–45,45f–46f
44 45 45 46