药物发现和开发的基本原则

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药物发现和开发的基本原则 1336条(本栏目收费,不能显示细节,电话13136136841)

Contextual fear conditioning model,317–318, 318f 317 318 318

Contract research organizations (CROs),457–460 457 460

Cyan fluorescent protein (CFP), 170–171 170 171

Cyclic adenosine monophosphate (cAMP)

signaling, 109–110, 109f, 134–135 109 110 109 134 135

Cyclooxygenase-1 (COX-1), 524–525 524 525

Cyclooxygenase-2 (COX-2), 415–416,524–525 415 416 524 525

Lind, James, 383–384, 384f 383 384 384

Liver microsomal stability

human liver microsome (HLM) stability,279–280, 280f, 282–283, 283f 279 280 280 282 283 283

mouse liver microsomes (MLM),280–281, 281f 280 281 281

rat liver microsomes (RLM), 279–282,280f, 282f 279 282 280 282

X-ray crystal-based models, 19 19

HMG-CoA reductase inhibitors, 13–14,16–18, 16f 13 14 16 18 16

Homologous animal models, 312 312

HSP90 inhibitors. See Heat shock protein90 (HSP90) inhibitors

Human chorionic gonadotropin (hCG), 424 424

Human Genome Project, 87 87

Human genomes, 87, 88f 87 88

Human immunodeficiency virus (HIV), 1 1

protease inhibitors, 169, 169f 169 169

Crixivan® (Indinavir), 508–510, 508f,510f 508 510 508 510

Human liver microsome (HLM) stability,279–280, 280f, 282–283, 283f 279 280 280 282 283 283

Human serum albumin (HSA), 268–269 268 269

Hypercholesterolemia, diet-induced model.

See Animal models, disease states,

cardiovascular disease animal

model; cholesterol

Hyperlipidemia. See Animal models,

disease states; cardiovascular

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