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托莫西汀-atomoxetine
变量_单倍型
CYP2D6*1, CYP2D6*89, CYP2D6*98
记事
Recombinant human CYP2D6 expressed in microsomes from insect cells. in vitro assay measuring the enzymatic activity using atomoxetine as substrate. intrinsic clearance is Vmax/Km. Variants that define *98 or *89 are not reported.
专家论述
CYP2D6 *89 + *98 are not associated with clearance of atomoxetine in microsomes from insect cells Sf21 as compared to CYP2D6 *1.