当前位置:药药网 / 数据中心 /变体注释摘要_体外和功能分析类型
托莫西汀-atomoxetine
变量_单倍型
CYP2D6*1, CYP2D6*94
记事
Recombinant human CYP2D6 expressed in microsomes from insect cells. in vitro assay measuring the enzymatic activity using atomoxetine as substrate. intrinsic clearance is Vmax/Km. Variants that define *94 are not reported.
专家论述
CYP2D6 *94 is associated with increased clearance of atomoxetine in microsomes from insect cells Sf21 as compared to CYP2D6 *1.