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托莫西汀-atomoxetine
变量_单倍型
CYP2D6 poor metabolizers
记事
Enzyme kinetic analyses of 4-hydroxy ATX (major metabolite) formation in A) 2 samples containing full complement of CYPs and B) 2 CYP2D6-deficient samples. A) CLint (Vmax/Km) are 50 and 155 B) CLint (Vmax/Km) are 0.1 and 0.3.
专家论述
CYP2D6 poor metabolizers are associated with decreased clearance of atomoxetine in human microsomes.