注释ID

1446900301

变量_单倍型

CYP2D6 poor metabolizers

基因

CYP2D6

药物名称(英)

doxepin

药物名称(中)

多虑平

PMID

11037801

类型

Metabolism/PK

含义

not stated

记事

Three human liver samples were tested for dextromethorphan o-demethylation activity as marker for CYP2D6 activity. Based on this 2 liver samples showed extensive metabolizer status (CYP2D6 activity 1.21 and 1.27 nmol/min/nmolP450), while one sample poor metabolizer status (CYP2D6 activity 0.03 nmol/min/nmolP450). Km was 6-9.6 microM for EM samples for E-doxepin. The PM sample had a similar Km value but only produced a small amount of E-hydroxydoxepin with less than one-tenth of Vmax of the EM samples. Studies with the CYP2D6 inhibitor quinidine suggests that CYP2D6 is catalyzing E-doxepin hydroxylation.

专家论述

CYP2D6 poor metabolizers are associated with decreased metabolism of doxepin in human liver microsomes as compared to CYP2D6 normal metabolizers.

等位基因

专家评论

变体注释摘要

id	研究类型	特征类型
26818		Study Cohort