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硝苯地平-nifedipine
记事
effect is described for CYP3A5.11 protein (mapped to suballele CYP3A5*3.008 on PharmVar), where protein studied has just the Tyr53Cys change on the CYP3A5*1 background. Variant has decreased Vmax, increased Km and decreased intrinsic clearance.
专家论述
Allele C is associated with decreased enzyme activity of CYP3A5 when assayed with nifedipine as compared to allele T.