注释ID

1446898923

变量_单倍型

CYP2D6*1, CYP2D6*17

基因

CYP2D6

药物名称(英)

"bufuralol","dextromethorphan"

药物名称(中)

“布呋洛尔”、“右美沙芬”

PMID

11950793

类型

Metabolism/PK

含义

yes

记事

The *17 construct (T107I, R296C and S486T) was expressed in cos-7 cells and the kinetic parameters Km and Vmax were determined for dextromethorphan and bufuralol compared to *1 construct. dextromethorphan: Km 2 fold increase to *1; Vmax 33% reduction. bufuralol: Km no effect compared to *1; Vmax 45% decrease compared to *1. Resulting in about 25 % (p<0.01) reduction in intrinsic clearance for dextromethorphan and 37% (p<0.02) for bufuralol for *17 compared to *1. CYP2D6 cDNA with *17=T105I, R296C; S486T variations. The intrinsic clearance for these substrates are also lower from *17 compared to *2 (p<0.05).

专家论述

CYP2D6 *17 is associated with decreased clearance of bufuralol or dextromethorphan in COS-7 cells as compared to CYP2D6 *1.

等位基因

*17

专家评论

变体注释摘要

id	研究类型	特征类型
26816		Drug
26815		Drug