注释ID

1446899382

变量_单倍型

CYP2D6*1, CYP2D6*2, CYP2D6*9, CYP2D6*25, CYP2D6*26, CYP2D6*28, CYP2D6*32, CYP2D6*43, CYP2D6*45, CYP2D6*70

基因

CYP2D6

药物名称(英)

n-desmethyltamoxifen

药物名称(中)

n-去甲基三苯氧胺

PMID

24647041

类型

Metabolism/PK

含义

no

记事

CYP2D6 cDNA was cloned and expressed in COS-7 cells to compare to constructs for CYP2D6*7, 10, 12, 14, 17, 18, 29, 30, 31, 35, 36, 37, 40, 46, 47, 50, 51, 52, 54, 55, 57, 61, 62, 63, 64, 65, 71, 72 constructs. For *2 (*2=R296C; S486T) + *9 (2615_2617delAAG)+ *25 (3198C>G) + *26 (3277T>C)+ *28 (19G>A, 1704C>G, 2850C>T)+ *32 (2850C>T, 3853G>A, 4180G>C)+ *43 (77G>A) + *45 (1716G>A, 2850C>T, 4180G>C) + *70 (1608G>A, 1659G>A, 1661G>C, 3183G>A, 4180G>C) containing constructs the intrinsic clearance for N-desmethyltamoxifen (N-desmethyltamoxifen 4-hydroxylation) was <50% as compared to *1 (*25 showed 53% of wild type) but these results were not statistically significant.

专家论述

CYP2D6 *2 + *9 + *25 + *26 + *28 + *32 + *43 + *45 + *70 are associated with decreased clearance of n-desmethyltamoxifen in COS-7 microsomes as compared to CYP2D6 *1.

等位基因

*2 + *9 + *25 + *26 + *28 + *32 + *43 + *45 + *70

专家评论

变体注释摘要

id	研究类型	特征类型
26814		Study Cohort