注释ID

1446897886

变量_单倍型

CYP2D6*1, CYP2D6*2, CYP2D6*10, CYP2D6*87, CYP2D6*90, CYP2D6*91, CYP2D6*93, CYP2D6*94, CYP2D6*95, CYP2D6*97, CYP2D6*98

基因

CYP2D6

药物名称(英)

dextromethorphan

药物名称(中)

右美沙芬

PMID

26310775

类型

Metabolism/PK

含义

yes

记事

The dextromethorphan O-demethylation activities were measured for *2 (R296C, S486T); *10 (P34S, S486T); *87 (A5V only, and missing the *100C>T of the *87 allele); *88 (V104A); *89 (L142S); *90 (K147R); *91 (C161S only, and missing the 2988G>A splice variant of the *91 allele); *93 (T249P); *94 (D337G only, missing the 100C>T of the *94 allele); *95(R388H only, missing the 100C>T of the *95 allele; *97 (F457L); *98 (H463D) constructs in insect cells. The intrinsic clearance was calculated as Vmax/Km. The relative clearance is in relation to *1. Relative clearance as % of wild-type: *2: 43.85; *10: 4.57; *90: 58.94; *91: 41.13; *93: 1.3; *94: 67.03; *95: 30.24; *97: 44.7; *98: 14.3. One-way analyses of variance with Dunnett鈥檚 tests.

专家论述

CYP2D6 *2 + *10 + *87 + *90 + *91 + *93 + *94 + *95 + *97 + *98 are associated with decreased clearance of dextromethorphan in insect microsomes as compared to CYP2D6 *1.

等位基因

*2 + *10 + *87 + *90 + *91 + *93 + *94 + *95 + *97 + *98

专家评论

变体注释摘要

id	研究类型	特征类型
26813		Drug