注释ID

1450664415

变量_单倍型

rs763625282

基因

CYP2C19

药物名称(英)

voriconazole

药物名称(中)

伏立康唑

PMID

30464555

类型

Metabolism/PK

含义

yes

记事

Caution: M136K amino acid change might or not be together with W212X. No information about the gene construct generation used for the assay, the article names the variant *3C (M136K). In table 1 it lists W212X as effect for *3C. However it is not clear if the *3 signature SNP (W212X) is included in the *3C M136K construct since the *3 signature SNP construct by itself results in not detectable enzyme activity. Intrinsic clearance is Vmax/Km. Relative clearance for M136K is 24.63% compared to *1 (no variants).

专家论述

Allele A is associated with decreased clearance of voriconazole in insect microsomes as compared to allele T.

等位基因

A

专家评论

变体注释摘要

id	研究类型	特征类型
26809		Unknown