注释ID

1451487220

变量_单倍型

rs2229774

基因

RARG

药物名称(英)

doxorubicin

药物名称(中)

阿霉素

PMID

32587261

类型

Toxicity

含义

yes

记事

Allele A on plus chromosomal strand, corresponds to 427L and allele G on plus chromosomal strand corresponds to 427S protein. Authors describe "Genetic correction of RARG-S427L to wild type resulted in reduced doxorubicin-induced double stranded DNA breaks, reactive oxygen species production, and cell death. Conversely, introduction of RARG-S427L increased susceptibility to doxorubicin. "

专家论述

Allele A is associated with increased sensitivity to doxorubicin in induced pluripotent stem cell derived cardiomyocytes as compared to allele G.

等位基因

A

专家评论

变体注释摘要

id	研究类型	特征类型