注释ID

1447521027

变量_单倍型

rs2868177

基因

POR

药物名称(英)

bupropion

药物名称(中)

安非他酮

PMID

26580670

类型

Metabolism/PK

含义

yes

记事

CYP2B6 activity was measured through bupropion hydroxylation. POR g.6593A > G AA homozygotes had a significantly lower mean ratio of AUC hydroxybupropion/AUC bupropion than AG and GG genotypes in the CYP2B6*1/*1, CYP2B6*1/*6, and CYP2B6*6/*6 groups (10.9 卤 1.82 vs. 19.7 卤 5.53, P < 0.001, 6.18 卤 0.284 vs. 12.1 卤 4.31, P = 0.011, and 6.94 卤 1.48 vs. 10.9 卤 2.39, P = 0.043, respectively).

专家论述

Genotypes AG + GG are associated with increased activity of CYP2B6 when exposed to bupropion as compared to genotype AA.

等位基因

AG + GG

专家评论

变体注释摘要

id	研究类型	特征类型
26803	cohort	Study Cohort