注释ID

1446898855

变量_单倍型

CYP2D6*1, CYP2D6*2

基因

CYP2D6

药物名称(英)

"bufuralol","dextromethorphan"

药物名称(中)

“布呋洛尔”、“右美沙芬”

PMID

11950793

类型

Metabolism/PK

含义

no

记事

The *2 construct (R296C and S486T) was expressed in cos-7 cells and the kinetic parameters Km and Vmax were determined for dextromethorphan and bufuralol compared to *1 construct. dextromethorphan: Km no difference to *1; Vmax 30% reduction. bufuralol: Km 30% increased compared to *1; Vmax no effect compared to *1. Resulting in about 30 % reduction in intrinsic clearance for *2 compared to *1 but not significant. CYP2D6 cDNA with *2=R296C; S486T variations.

专家论述

CYP2D6 *2 is associated with decreased clearance of bufuralol or dextromethorphan in COS-7 cells as compared to CYP2D6 *1.

等位基因

*2

专家评论

变体注释摘要

id	研究类型	特征类型
26802		Study Cohort