记事
CYP2D6 cDNA was cloned and expressed in COS-7 cells to compare to constructs for CYP2D6*7, 10, 12, 14, 17, 18, 29, 30, 31, 35, 36, 37, 40, 46, 47, 50, 51, 52, 54, 55, 57, 61, 62, 63, 64, 65, 71, 72 constructs. Assaying the *53 (F120I; A122S) construct yielded in a decreased Km (p<0.05) and increased Vmax (p<0.005) compared to *1, which led to an increased intrinsic clearance of 2786% compared to the results with the *1 construct.