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巯基嘌呤-mercaptopurine
变量_单倍型
TPMT*1, TPMT*3A, TPMT*4
记事
A family pedigree with ten members was studied. Individuals who had low TPMT activity were found to have the *3A/*4 genotype (n=2), individuals who had intermediate TPMT activity were found to have the *1/*3A (n=3) or *1/*4 (n=3) genotype. TPMT activity measured using radiochemical enzymatic assay in RBC lysates.
专家论述
TPMT *1/*3A + *3A/*4 + *1/*4 are associated with decreased enzyme activity of TPMT when assayed with mercaptopurine.
等位基因
*1/*3A + *3A/*4 + *1/*4