巯基嘌呤-mercaptopurine
注释ID
1184134177
变量_单倍型
TPMT*1, TPMT*2, TPMT*3A, TPMT*3C
基因
TPMT
药物名称(英)
mercaptopurine
药物名称(中)
巯基嘌呤
PMID
11372592
类型
Metabolism/PK
含义
not stated
记事
There were 3 *1/*1 subjects whose assays showed decreased TPMT activity which overlapped the high end of the range of the heterozygous subjects (heterozygote range = 0.21 pmol/min/mg - 0.30 pmol/min/mg). The rest of the *1/*1 subjects had activity levels between 0.31 pmol/min/mg and 0.80 pmol/min/mg. Assays were done for TPMT*2, TPMT*3A, TPMT*3B and TPMT*3C. There were 8 *1/*3A, 2 *1/*3C and 1 *1/*2.
专家论述
TPMT *1/*2 + *1/*3A + *1/*3C is associated with decreased activity of TPMT when assayed with mercaptopurine in erythrocyte lysates as compared to TPMT *1/*1.
等位基因
*1/*2 + *1/*3A + *1/*3C
专家评论
变体注释摘要
id研究类型特征类型
26780 cohort Study Cohort
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