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记事
Significantly lower abundance of UGT1A1 protein was observed in human liver microsomes from individuals with the variant allele rs10929302 (*93; c.3156G>A). The association between age and protein abundance diminished in human liver microsome samples in cells carrying hetero- or homozygous variant alleles.
专家论述
Allele A is associated with decreased concentrations of UGT1A1 in human liver microsomes as compared to allele G.