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巯基嘌呤-mercaptopurine
变量_单倍型
TPMT*1, TPMT*2, TPMT*3A, TPMT*3C
记事
The individuals were selected for genotyping based on their TPMT enzymatic activity. Genotyping assays were done for the SNPS involved in *2,*3A,*3B,*3C,*3D,*4,*5,*6,*7,*8,*11,*10. Genotypes were grouped by PharmGKB.
专家论述
TPMT *1/*2 + *1/*3A + *3A/*3A + *3A/*3C are associated with decreased activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.
等位基因
*1/*2 + *1/*3A + *3A/*3A + *3A/*3C