“美苯妥英”、“奥美拉唑”-"mephenytoin","omeprazole"
注释ID
1184565081
变量_单倍型
rs55948420
基因
CYP2C19
药物名称(英)
"mephenytoin","omeprazole"
药物名称(中)
“美苯妥英”、“奥美拉唑”
PMID
19661214
类型
Metabolism/PK
含义
no
记事
Healthy volunteers (113 Vietnamese and 94 Korean) received a single 20 mg dose of omeprazole after overnight fasting. Blood samples were taken 3 hr after administration of omeprazole. Samples from volunteers with 1) 1/*2 or *1/*3 genotypes and 2) a metabolic ratio (MR) of omeprazole/ 5-hydroxyomeprazole that was higher than the average MR for *2/*2 or *3/*3 underwent direct DNA sequencing of CYP2C19 to search for novel variants responsible for the high MR. The corresponding variants were recreated by site-directed mutagenesis of CYP2C19 cDNA which was integrated into plasmids and transfected into DH5 alpha "E.coli" cells. CYP2C19 protein variants were eluted and tested for their effect on enzymatic activity. *Note: the protein change that corresponds to rs55948420 A is V394M which has no associated *allele.
专家论述
Allele A is not associated with catalytic activity of CYP2C19 when exposed to mephenytoin and omeprazole as compared to allele G.
等位基因
A
专家评论
变体注释摘要
id研究类型特征类型
26772 Drug
26771 Drug
免责声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责,医药网对此不承担任何责任。
相关链接:医药研究数据| 医药资料| SDA药品评审中心| 中医网| 中药处方系统| 爱视立眼贴
专业提供药品信息、药品招商、药品代理、保健品招商、医药原料采购供应的中国药品信息网站平台
版权所有 © 2003-2028 盗冒必究  客服热线:0575-83552251 / 13754370441  QQ客服:药品信息客服
浙ICP备16010490号-2 增值电信业务经营许可证:浙B2-20220931 互联网药品信息服务资格证书编号:(浙)-经营性2023-0215 浙公网安备:330683240604819103159
 医药代理商群1:药药网药品采购交流医药代理商群2:药药网药品采购交流2医药代理商群3:药药网药品采购交流3