氯吡格雷-clopidogrel
注释ID
1184516565
变量_单倍型
CYP2C19*1, CYP2C19*10, CYP2C19*13, CYP2C19*14, CYP2C19*15, CYP2C19*18, CYP2C19*19, CYP2C19*23, CYP2C19*25, CYP2C19*26
基因
CYP2C19
药物名称(英)
clopidogrel
药物名称(中)
氯吡格雷
PMID
25001882
类型
Metabolism/PK
含义
yes
记事
The Km, Vmax and CLint values for clopidogrel 2-oxidation were measured and compared to *1B. Although differences in Vmax compared to *1B are found for *1A, *10, *13, *14, *15, *18, *19, *23, *25, *26, the Km value only differed for *19 and *26. The clearance was affected for *10, *14, *19, *23, *25, *26. Please note the article separated *1A and *1B.
专家论述
CYP2C19 *10 + *13 + *14 + *15 + *18 + *19 + *23 + *25 + *26 are associated with decreased catalytic activity of CYP2C19 when exposed to clopidogrel in cos-7 cells as compared to CYP2C19 *1.
等位基因
*10 + *13 + *14 + *15 + *18 + *19 + *23 + *25 + *26
专家评论
变体注释摘要
id研究类型特征类型
26770 Drug
26769 Drug
免责声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责,医药网对此不承担任何责任。
相关链接:医药研究数据| 医药资料| SDA药品评审中心| 中医网| 中药处方系统| 爱视立眼贴
专业提供药品信息、药品招商、药品代理、保健品招商、医药原料采购供应的中国药品信息网站平台
版权所有 © 2003-2028 盗冒必究  客服热线:0575-83552251 / 13754370441  QQ客服:药品信息客服
浙ICP备16010490号-2 增值电信业务经营许可证:浙B2-20220931 互联网药品信息服务资格证书编号:(浙)-经营性2023-0215 浙公网安备:330683240604819103159
 医药代理商群1:药药网药品采购交流医药代理商群2:药药网药品采购交流2医药代理商群3:药药网药品采购交流3