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氯吡格雷-clopidogrel
变量_单倍型
CYP2C19*1, CYP2C19*28
记事
association compared to *1B. Please note the article separated between *1A and *1B. While the Vmax was increased compared to *1B the Vmax for *1A was decreased compared to *1B. For both * alleles no-significant difference was shown for Km values.
专家论述
CYP2C19 *28 is associated with increased catalytic activity of CYP2C19 when exposed to clopidogrel in cos-7 cells as compared to CYP2C19 *1.