注释ID

1184484046

变量_单倍型

rs8330

基因

UGT1A4

药物名称(英)

tamoxifen

药物名称(中)

他莫昔芬

PMID

24917585

类型

Metabolism/PK

含义

yes

记事

Microsomes from individuals homozygous for the C allele had significantly lower 4-OH-tamoxifen-O-glucuronidation, as compared to those with the CG or GG genotype. A borderline significant result (p=0.053) was seen when considering 4-OH-toremifene-O-glucuronidation. No significant result was seen when considering Tamoxifen-N-glucuronidation (p = 0.79), 4-OH-tamoxifen-N-glucuronidation (p = 0.67), Toremifene-N-glucuronidation (p = 0.47), or 4-OH-toremifene-N-glucuronidation (p = 0.49). UGT enzymes like UGT1A4 are responsible for the glucuronidation of compounds such as tamoxifen, leading to metabolites like the ones mentioned above.

专家论述

Genotype CC is associated with decreased activity of UGT1A4 when exposed to tamoxifen in human liver microsomes as compared to genotypes CG + GG.

等位基因

CC

专家评论

变体注释摘要

id	研究类型	特征类型
26737	cohort	Unknown