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氟尿嘧啶-fluorouracil
记事
Functional study. The G allele was associated with DPYD activity at 99% of wild-type, a non-significant difference. Activity measured by conversion of 5-fluorouracil to 5-dihydrofluorouracil, the product of DPYD catabolism. Using PolyPhen-2, this variant was classified as "benign". Please note that this SNP was referred to by its amino acid change (K875Q) within the paper.
专家论述
Allele G is not associated with activity of DPYD when assayed with fluorouracil as compared to allele T.