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布呋洛尔-bufuralol
变量_单倍型
CYP2D6*1, CYP2D6*36
记事
Bufuralol 1 鈥?hydroxylation assays were performed with cell homogenates corresponding to 1.2 mg of protein. Construct expressing *36 variants (P34S and conversion to CYP2D7 in exon 9) showed nearly no OH- bufuralol formation.
专家论述
CYP2D6 *36 is associated with decreased catalytic activity of CYP2D6 when exposed to bufuralol in COS-1 cells as compared to CYP2D6 *1.