注释ID

1448532517

变量_单倍型

CYP2D6*1, CYP2D6*10, CYP2D6*87, CYP2D6*88, CYP2D6*90, CYP2D6*91, CYP2D6*93, CYP2D6*95, CYP2D6*97

基因

CYP2D6

药物名称(英)

olanzapine

药物名称(中)

奥氮平

PMID

27251229

类型

Metabolism/PK

含义

yes

记事

The the conversion of olanzapine to 2-hydroxymethylolanzapine was measured for *2 (R296C, S486T); *10 (P34S, S486T); *87 (A5V); *88 (V104A); *89 (L142S); *90 (K147R); *91 (C161S); *93 (T249P); *94 (D337G); *95(R388H); *97 (F457L); *98 (H463D) constructs in insect cells. The intrinsic clearance was calculated as Vmax/Km. The relative clearance is in relation to *1. No information about *1 construct but might be cDNA. Clearance in % *10: 5.2 *87: 26.0 *88: 78.9 *90: 75.8 *91: 75.7 *93: 17.7 *95: 68.4 *97: 75.3. Note, most constructs are only including a single variant even though the star alleles are defined by a combination of variants, e.g. *87, *94, *95 are missing the 100C>T P34S variant in the construct used for the in-vitro assay and *91 is missing the 2989G>A (splicing defect) variant.

专家论述

CYP2D6 *10 + *87 + *88 + *90 + *91 + *93 + *95 + *97 are associated with decreased clearance of olanzapine as compared to CYP2D6 *1.

等位基因

*10 + *87 + *88 + *90 + *91 + *93 + *95 + *97

专家评论

变体注释摘要

id	研究类型	特征类型
31596		Drug