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苯妥英钠-mephenytoin
变量_单倍型
CYP2C19*1, CYP2C19*10
记事
For *10, rs6413438 was assayed. CYP2C19.1B was used as the comparison and is described as "wild-type". For 2-oxo-clopidogrel, the difference in intrinsic clearance was significant (not stated for clopidogrel). *10 acted as a loss-of-function variant for S-mephenytoin metabolism.
专家论述
CYP2C19 *10 is associated with decreased catalytic activity of CYP2C19 when assayed with mephenytoin in E. coli DH5alpha as compared to CYP2C19 *1.