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SN-38-SN-38
记事
Human liver microsomes with the CT and TT genotypes had 2.43-fold and 1.66-fold higher median formation of the SN-38 glucuronide metabolite (SN-38G), as compared to those with the CC genotype. SN-38 is the active metabolite of irinotecan, and is metabolized via glucuronidation by members of the UGT1A family.
专家论述
Genotypes CT + TT is associated with increased clearance of SN-38 in human liver microsomes as compared to genotype CC.