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巯基嘌呤-mercaptopurine
变量_单倍型
TPMT*1, TPMT*3A, TPMT*3C
记事
The mean activity of the TPMT *1/*1 group was higher than that of the *1/*3 group (*3A or *3C not determined) at 13.1(95% CI 12.5-13.7) IU/mL vs 8.3 (95% CI 6.8-9.8 IU/mL). But, 4/61 *1/*1 subjects had TPMT activity in the intermediate range, and 2/7 of the *1/*3 subjects had activity in the normal range. Patients were also genotyped for *2.
专家论述
TPMT *1/*1 is associated with increased enzyme activity of TPMT when assayed with mercaptopurine in red blood cell lysates as compared to TPMT *1/*3A + *1/*3C.