注释ID

1184472791

变量_单倍型

rs7867504

基因

SLC28A3

药物名称(英)

gemcitabine triphosphate ditriethylamine

药物名称(中)

三磷酸吉西他滨二三乙胺

PMID

24300978

类型

Metabolism/PK

含义

yes

记事

Gemcitabine, gemcitabine triphosphate (dFdCTP), and de-aminated gemcitabine (dFdU) plasma concentrations were measured before (5, 15, 30, 45 min) and after gemcitabine infusion (1, 1.25, 1.5, 2, 6, 24, 48, 72 hrs). Population pharmacokinetic analysis of gemcitabine and metabolites (dFdU, dFdCTP) were performed by non-linear mixed effects modeling. Pharmacokinetics of dFdCTP were described by a three-compartment model. SLC28A3 rs7867504 genotype was associated with formation of dFdCTP, a pharmacologically active metabolite of gemcitabine. The CC genotype was associated with a 1.77 fold increase in formation of dFdCTP (gemcitabine triphosphate).

专家论述

Genotype CC is associated with increased formation of gemcitabine triphosphate ditriethylamine.

等位基因

CC

专家评论

变体注释摘要

id	研究类型	特征类型
26751	prospective	Study Cohort