注释ID

1184518521

变量_单倍型

CYP2C19*1, CYP2C19*15

基因

CYP2C19

药物名称(英)

"fluvoxamine","omeprazole"

药物名称(中)

“氟伏沙明”、“奥美拉唑”

PMID

21692664

类型

Metabolism/PK

含义

yes

记事

The fluorogenic substrate 3-cyano-7-ethoxycoumarin (CEC) was incubated with CYP2C19 microsomal protein harboring human CYP2C19 variants to assay enzyme activity, standardized to protein concentration. "Sensitivity" refers to the extent of inhibition relative to CYP2C19*1A (WT) and quantified by IC50. The inhibitory effect of the following drugs was tested for each CYP2C19 variant: celecoxib, troglitazone, fluconazole, ketoconzale, omeprazole, ticlopidine, fluoxetine, sertraline, fluvoxamine, tranylcypromine.

专家论述

CYP2C19 *15 is associated with increased sensitivity to fluvoxamine and omeprazole as compared to CYP2C19 *1.

等位基因

*15

专家评论

变体注释摘要

id	研究类型	特征类型
27063		Drug