巯基嘌呤-mercaptopurine
注释ID
1184269585
变量_单倍型
TPMT*1, TPMT*3C
基因
TPMT
药物名称(英)
mercaptopurine
药物名称(中)
巯基嘌呤
PMID
19048245
类型
Metabolism/PK
含义
yes
记事
Kidney Transplant patients treated with azathioprine were genotyped for *2,*3A,*3B and *3C alleles. Out of 150 patients, seven were *1/*3C, and all of these cases had intermediate TPMT activity (defined here as 13.04-23.70 U). Mean activity for this group was 16.75 +/- 2.09 U, which was significantly lower than that of *1/*1 patients. 17 patients with intermediate activity were typed as *1/*1.
专家论述
TPMT *1/*3C is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.
等位基因
*1/*3C
专家评论
变体注释摘要
id研究类型特征类型
27062 cohort Disease
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