当前位置:药药网 / 数据中心 /变体注释摘要_体外和功能分析类型
巯基嘌呤-mercaptopurine
记事
Kidney Transplant patients treated with azathioprine were genotyped for *2,*3A,*3B and *3C alleles. Out of 150 patients, seven were *1/*3C, and all of these cases had intermediate TPMT activity (defined here as 13.04-23.70 U). Mean activity for this group was 16.75 +/- 2.09 U, which was significantly lower than that of *1/*1 patients. 17 patients with intermediate activity were typed as *1/*1.
专家论述
TPMT *1/*3C is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.