注释ID

1184269585

变量_单倍型

TPMT*1, TPMT*3C

基因

TPMT

药物名称(英)

mercaptopurine

药物名称(中)

巯基嘌呤

PMID

19048245

类型

Metabolism/PK

含义

yes

记事

Kidney Transplant patients treated with azathioprine were genotyped for *2,*3A,*3B and *3C alleles. Out of 150 patients, seven were *1/*3C, and all of these cases had intermediate TPMT activity (defined here as 13.04-23.70 U). Mean activity for this group was 16.75 +/- 2.09 U, which was significantly lower than that of *1/*1 patients. 17 patients with intermediate activity were typed as *1/*1.

专家论述

TPMT *1/*3C is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.

等位基因

*1/*3C

专家评论

变体注释摘要

id	研究类型	特征类型
27062	cohort	Disease