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巯基嘌呤-mercaptopurine
变量_单倍型
TPMT*1, TPMT*3A, TPMT*3C
记事
Genotyping was performed for *2,*3A,and *3C. There was no overlap in activity range of the *1/*3A subjects as compared to the *1/*1 subjects. Activity was 17 +/- 3.6 for *1/*3A vs. 32.4 +/- 4.8 nmol 6-mMP/g Hb/h for *1/*1.
专家论述
TPMT *1/*3A is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.