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巯基嘌呤-mercaptopurine
记事
Out of 229 healthy subjects with activity > 10.07 nmol/h/ml pLRBC, none had a variant allele (genotyping was done for *2,*3A,*3B,*3C). Seven of 19 subjects with activity at or below 10.07 nmol/h/ml pLRBC were *1/*3C. 12 of 241 subjects typed as *1/*1 had a reduced TPMT activity of 7.14-10.06 nmol/h/ml pRBC.
专家论述
TPMT *1/*3C is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in red blood cells as compared to TPMT *1/*1.