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巯基嘌呤-mercaptopurine
变量_单倍型
TPMT*1, TPMT*3B, TPMT*3C
记事
Genotype assays were performed for *2,*3A,*3B,and *3C. There was one *3B/*3C subject, whose assay showed very low TPMT activity (1.6 U/gHb). *1/*1 subjects had assay results ranging from 8.3-75.2 U/gHb. Authors stated that the results were adjusted for multiple hypothesis testing. They observed a 4-group distribution of TPMT activity phenotypes.
专家论述
TPMT *3B/*3C is associated with decreased enzyme activity of TPMT when assayed with mercaptopurine in erythrocyte lysates as compared to TPMT *1/*1.